Clavia Ruth Wooton - Kee , David E . Cohen and Mary Vore of the bile acid pool in the lactating rat - hydroxylase expression and size α Increased cholesterol 7
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of the bile acid pool in the lactating rat-hydroxylase expression and size α Increased cholesterol 7 You might find this additional info useful... published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. It is publishes original articles pertaining to all aspects of research AJP-Gastrointestinal and Liver Physiology
منابع مشابه
ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats.
Lactation is associated with increased expression of bile acid transporters and an increased size and hydrophobicity of the bile acid pool in rats. ATP-binding cassette (ABC) transporters multidrug resistance protein 2 (Mdr2), Abcb11 [bile salt export pump (Bsep)], and Abcg5/Abcg8 heterodimers are essential for the biliary secretion of phospholipids, bile acids, and cholesterol, respectively. W...
متن کاملIleal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits.
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits. Bile acid pool sizes, fecal bile acid outputs (synthesis rates), and the activities of cholesterol 7alpha-hydroxylase (classic bile acid synthesis) and cholesterol 27-hydroxylase (alternative bile acid synthesis) were related to ileal bile...
متن کاملThe pool of free cholesterol is not of major importance for regulation of the cholesterol 7 alpha-hydroxylase activity in rat liver microsomes.
The relationship between the cholesterol 7 alpha-hydroxylase activity and the pool of free cholesterol in rat liver microsomes was studied under experimental conditions aimed to stimulate (biliary drainage, cholestyramine treatment, and lymphatic drainage) as well as inhibit (chenodeoxycholic acid treatment) bile acid synthesis. Highly accurate methods based on isotope dilution-mass spectrometr...
متن کاملAlternate pathways of bile acid synthesis in the cholesterol 7 a -hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding
Bile acids are synthesized via the classic pathway initiated by cholesterol 7 a -hydroxylase (CYP7A1), and via alternate pathways, one of which is initiated by sterol 27hydroxylase (CYP27). These studies used mice lacking cholesterol 7 a -hydroxylase ( Cyp7a1 2 / 2 ) to establish whether the loss of the classic pathway affected cholesterol homeostasis differently in males and females, and to de...
متن کاملLipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7alpha-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes.
Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7alpha-hydroxylase expression. However, the effect of lipoprotein cholesterol on sterol 27-hydroxylase expression and the role of different lipoproteins in regulating both enzymes are not well established. We studied the effect of dif...
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تاریخ انتشار 2008